Marvel Super Heroes and Street Fighter uses the same tag-team format previously employed in X-Men and Street Fighter. In addition to all the features introduced, the player can now summon their partner to perform one of their special moves without changing their currently-controlled character. Most of the Street Fighter characters from the previous game returned, with the exception of Cammy and Charlie, who are replaced by Dan and Sakura. However, all of the X-Men characters from the previous game (with the exception of Cyclops and Wolverine) are replaced with characters from Marvel Super Heroes (and Omega Red from X-Men). Like in X-Men and Street Fighter, the single-player mode consists of matches against other tag-teams and a two-on-one fight against Apocalypse. However, the match against the player's default character and his partner is replaced with another two-on-one match, this time against a cyborg version of Akuma. The character who deals the finishing blow to Cyber-Akuma will have their ending played.